Hookworm-Associated Reactive Spondyloarthritis

Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis

INTRODUCTION Both reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activit...

An increase in hookworm infection temporally associated with ecologic change.

This report describes a significant increase in the prevalence of hookworm infection in an area of Haiti where intestinal parasites are common, but hookworm has not been common. Changing environmental conditions, specifically deforestation and subsequent silting of a local river, have caused periodic flooding with deposition of a layer of sandy loam topsoil and increased soil moisture. We specu...

Role for nitric oxide in hookworm-associated immune suppression.

Hookworm infection is a major cause of anemia and malnutrition in resource-poor countries. Human and animal studies suggest that infection with these intestinal nematodes is associated with impaired cellular immunity, characterized by reduced lymphocyte proliferation in response to both parasite and heterologous antigens. We report here data from studies aimed at defining mechanisms through whi...

Hookworm Infection

Spondyloarthritis – Associated Hla-b Phenotypes in Northeastern Romania Population

Aim: The aim of our survey was to identify spondyloarthritis – associated to HLA -B phenotypes in the population from north-eastern part of Romania. Genetic (HLA or nonHLA genes) and infectious factors are involved in determining spondyloarthritis susceptibility and severity. The most frequent association is with HLA-B27 antigen, but the extent of association of this antigen with spondyloarthri...